Naslov
Synthesis and Antiproliferative Activity of new Amidino-substituted Furanocarboxyanilides

Autori
Jarak, Ivana ; Kralj, Marijeta ; Marjanović, Marko ; Pavelić, Krešimir ; Piantanida, Ivo ; Žinić, Mladen ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka = Book of abstracts / Rapić, Vladimir ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2005, 141-141

Skup
Hrvatski skup kemičara i kemijskih inženjera (19 ; 2005)

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
amidino-supstituted furancarboxanilides; antiproliferative activity; DNA binding

Sažetak
Amidino-substituted amides exhibit various biological activities, such as anti-cancer and anti-bacterial activity [1, 2]. New benzoamidino-substituted furancarboxanilides were prepared by multistep synthesis from corresponding nitriles using Pinner reaction or by direct condensation of corresponding acyl-chlorides with p-amino-N-(isopropyl)benzo-amidine. All prepared compounds were tested on their antiproliferative activities. In addition, their interactions with ds DNA and RNA were studied by spectroscopic titrations and thermal denaturation experiments.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA