Naslov
Antibiotic susceptibilities and ß-lactamase production of Moraxella catarrhalis isolates from Zagreb, Croatia

Autori
Bedenić, Branka ; Vraneš, Jasmina

Izvornik
Acta clinica Croatica (0353-9466) 43 (2004), 4; 365-370

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Moraxella catarrhalis; beta-lactamases; amoxycillin; clavulanate; cephalosporins

Sažetak
Moraxella catarrhalis a commensal of the nasopharynx has been recognized with increasing frequency as a potential pathogen in respiratory tract infections. The beta-lactamase production in M. catarrhalis first described in 1977 has been reported with increasing frequency in many countries of the world. However, there were no reports from Croatia so far. The aim of this study was to investigate antibiotic susceptibilities and beta-lactamase production in M. catarrhalis isolates from Croatia. Fifty M. catarrhalis strains were collected in University Children's Hospital Zagreb during 1990-1992 from various clinical specimens. Antibiotic susceptibilities to wide range of antibiotics were determined by broth microdilution method according to NCCLS. Beta-lactamases were detected by disk chromogenic substrate (nitrocephin) test in all strains. Prevalence of beta-lactamase positive strains in the study period was 100%. No resistance to amoxycillin/clavulanate, cephalexin, ceftibuten, tetracycline, erythromycine, azitromycine and chloramphenicol was observed. The activity of amoxycillin was strongly enhanced in the presence of clavulanic acid in all strains. Older cephalosporins were equally active but third generation cephalosporin ceftibuten displayed significantly lower MICs compared to older compounds. Among non beta-lactam antibiotics tetracycline and eritromycine showed similar activity. Azithromycine had markedly stronger inhibitory activity on comparison with erythromycine and tetracycline. According to our results amoxycillin combined with clavulanic acid should be the antibiotic of choice for the treatment of infections caused with beta-lactamase positive isolates of M. catarrhalis. Oral cephalosporins, tetracycline, macrolides or azithromycine could be an option too.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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