Naslov
Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid

Autori
Jernej, Branimir ; Štefulj, Jasminka ; Hranilović, Dubravka ; Balija, Melita ; Kubat, Milovan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Ambriović Ristov, Andreja ; Brozović, Anamarija - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003, 48-48

Skup
2nd Scientific Symposium With International Participation

Mjesto i datum
Zagreb, Hrvatska, 20.11.2003. - 21.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
-

Sažetak
Recent epidemiological studies revealed the role of genetic factors in the predisposition to sucide, which is now considered a disorder sui generis, independent of concomitant psychiatric disorder. Indices of disturbed serotonergic neurotransmission are the most robust biological findings in suicide. Serotonergic neurotransmission is controlled by two main mechanisms: synthesis of the transmitter, regulated by the rate limiting tryptophan hydroxylase (TPH), and termination of transmission, mediated by 5-hydroxytryptamine transporter (5HTt). Intronic polymorphisms have been identified in both TPH (218AC in intron 7) and 5HTt (VNTR, with 12 and 10 repeats) genes. In the present work, we investigated whether the concurrence of two suspected, allegedly transcriptionally less active, variants (TPH allele C and 5HTt allele 10) represented the increased risk for suicidal behavior.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA