Naslov
A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses

Autori
Zimmermann, Albert ; Trilling, Mirko ; Wagner, Markus ; Wilborn, Manuel ; Bubić, Ivan ; Jonjić, Stipan ; Koszinowski, Ulrich ; Hengel, Hartmut

Izvornik
The Journal of experimental medicine (0022-1007) 201 (2005), 10; 1543-1553

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cytomegalovirus; IFN-g; STAT; immune evasion

Sažetak
A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79 kDa protein which is selcetively binding and down-regulating STAT2 but has no effect on STAT1 activation and signaling. The absence of pM27 conferred MCMV susceptibility to type I IFNs (a/b) but had a much more dramatic effect to type II IFN (g) in vitro and in vivo. Comparative analysis of M27+ and M27- MCMV revealed that the antiviral efficiency of IFN-g was partially dependent on the synergistic action of type I IFNs which required STAT2. Moreover, STAT2 was directly activated by IFN-g. This effect required IFNGR expression and was independent of type I IFNs. IFN-g induced incerasing levels of tyrosine-phosphorylated STAT2 in M27- MCMV infected cells which were esential for the antiviral potency of IFN-g. pM27 represents a new strategy for simultaneous evasion from type I and type II IFN and documents a hitherto unknown biological significance of STAT2 in antiviral IFN-g responses.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA