Naslov
Changes of lymphoid homeostasis and inhibition of liver regeneration provoked by sandostatin in mice

Autori
Ćuk, Mira ; Radošević-Stašić, Biserka ; Milin, Čedomila ; Mrakovčić-Šutić, Ines ; Barac-Latas, Vesna ; Petković, Marija ; Muhvić, Damir ; Verbanac, Donatella ; Rukavina, Daniel

Izvornik
Periodicum biologorum (0031-5362) 92 (1990), 1; 38-39

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lymphoid homeostasis; liver regeneration; sandostatin

Sažetak
Compensatory liver growth (CLG) may be significatly inhibited by treatment with Sandostatin (SMS), but the data show that some inhibitory effects might also be provoked by the concommitant stress related to the procedure of repeated injecting. Some inhibiting effects on hepatic DNA was obtained by SMS also in sham hepatectomized (Hx) mice, but similar changes were not seen in the liver of unoperated animals indicating the greater modulatory action of SMS on liver cells activated by partial hepatectomy (pHx) or operative stress. Analysis of the lymphohematopoetic status of the same animals however, has shown that SMS particularly affects the lymphatic organs of partially Hx mice. In these animals SMS potentiated the depletion of bone marrow and thymus and produced a significant hypoplasia of spleen. These results suggest growth and immunoregulatory properties of SMS especially after disturbance of morphostasis by pHx.

Izvorni jezik
Engleski

POVEZANOST RADA