Naslov
Novel Cyano- and N-isopropylamidino-Substituted Derivatives of Benzo[b]thiophene- 2-carboxanilides and Benzo[b]thieno[2, 3-c]quinolones: Synthesis, Photochemical Synthesis, Crystal Structure Determination and Antitumor Evaluation. Part 2.

Autori
Jarak, Ivana ; Kralj, Marijeta ; Šuman, Lidija ; Pavlović, Gordana ; Dogan, Jasna ; Piantanida, Ivo ; Žinić, Mladen ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
Journal of medicinal chemistry (0022-2623) 48 (2005); 2346-2360

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
benzo[b]thieno[2; 3-c]quinolones; synthesis; photochemical synthesis; intercalators; binding on DNA; anticancer activity

Sažetak
A series of new derivatives of 3-chloro-benzo[b]thiophene-2-carboxanilides (groups 2, 4, 5, 7, 8) and their "cyclic" analogues benzo[b]thieno[2, 3-c]quinolones were synthesized. Spectroscopic study of interactions of some representatives of "cyclic" derivatives and their "acyclic" precursors with ds-DNA/RNA supported strong intercalative binding of former and weak non-intercalative binding of later group of compounds. All tested compounds showed certain antiproliferative effect toward series of human tumor and one normal cell line. Among them those with one amidino- substituent have shown the best effect. The most active benzo[b]thieno[2, 3-c]quinolones induced apparent S and G2/M arrest of the cell cycle, which resulted in apoptosis. These results strongly suggested that the compounds may act as topoisimerase "poisons", what is in good agreement with their intercalative mode of binding to ds- DNA/RNA, opposite to studied "acyclic" group of derivatives. 6a and 6d showed the best selectivity by inhibiting the growth of tumor cells but not the normal fibroblasts

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA