Pregled bibliografske jedinice broj: 185879
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator // Journal of the American Chemical Society, 127 (2005), 1074-1075 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 185879 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator
Autori
Starčević, Kristina ; Karminski-Zamola, Grace ; Piantanida, Ivo ; Žinić, Mladen ; Šuman, Lidija ; Kralj, Marijeta
Izvornik
Journal of the American Chemical Society (0002-7863) 127
(2005);
1074-1075
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
amidines; photoinduced anticancer therapy
Sažetak
Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photodynamic anticancer therapy.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Profili:
Ivo Piantanida
(autor)
Lidija Šuman
(autor)
Grace Karminski-Zamola
(autor)
Mladen Žinić
(autor)
Marijeta Kralj
(autor)
Kristina Starčević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
