Naslov
Metal tissue kinetics in regenerating liver, thymus, spleen and submandibular gland after partial hepatectomy in mice

Autori
Milin, Čedomila ; Marin, Tota ; Domitrović, Robert ; Giacometti, Jasminka ; Pantović, Radojka ; Ćuk, Mira ; Mrakovčić-Šutić, Ines ; Jakovac, Hrvoje ; Radošević-Stašić, Biserka

Izvornik
Biological trace element research (0163-4984) 108 (2005); 225-243

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
zinc; calcium; magnesium; iron; partial hepatectomy; liver; thymus; spleen; submandibular gland

Sažetak
Liver regeneration that follows after partial hepatectomy (pHx) is well-defined process, which involves the concerted action of extra and intracellular factors resulting in induction of cell replication and its inhibition at time when the entire liver mass is restored. Concomitantly, the breakdown of previously maintained tolerance and the exposure of self antigens lead to the activation of pre-immune and immune repertoire, which participate in surveillance against aberrant cells and re-establishment of previous morphostasis. Since, in these events, important biological function might have tissue minerals which are affecting the structural integrity and enzyme activities, transduction signals, transcription and replication factors during cell proliferation and apoptosis, as well as, the development and maintenance of immune functions and cytokine production, in this study we analyzed tissue dynamics of zinc, iron, magnesium and calcium in the liver, thymus, spleen and submandibular gland in intact and pHx mice on the 1st, 2nd, 7th and 15th day after 1/3 pHx, using the microwave digestion and inductivity coupled plasma spectrometry. The data showed that pHx induces significant and interconnected changes in the all estimated metals not only in the regenerating liver, but also in the lymphatic tissues and submandibular gland, indicating their importance for the control of growth processes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA