Naslov
Immune responsiveness in offspring of adoptively immunized mothers

Autori
Dorić, Miljenko ; Rukavina, Daniel ; Jonjić, Stipan

Izvornik
Immunobiology (0171-2985) 172 (1986), 1-2; 92-98

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adoptive transfer ; offspring

Sažetak
The rate of appearance of cells forming 19S hemolytic antibody (PFC) in the spleens of F1 newborn mice after adoptive anti-paternal immunization of fetuses, newborns and/or their mothers during pregnancy has been studied. An increase in the number of PFC was found at the age of 6 to 11 days in offspring of adoptively immunized mothers. These newborns, even when foster nursed by untreated mothers, still had a significantly higher number of PFC in comparison to the controls. In contrast, adoptive immunization of the newborns themselves resulted in a decrease of PFC during the second week after birth. Several possible explanations for the obtained results are discussed including the putative transplacental passage of immunocompetent cells.

Izvorni jezik
Engleski

POVEZANOST RADA