Naslov
Chorionic villus sampling for prenatal diagnosis in Zagreb: experience with 4000 cases

Autori
Podobnik, Mario ; Podgajski, Mario ; Duić, Željko ; Podobnik, Petra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
The Journal of Maternal-Fetal & Neonatal Medicine / Di Renzo, Gian Carlo ; Maulik, Dev ; Didrik Saugstad, Ola - : The Parthenon Publishing Group, 2004

Skup
XIX European Congress of Perinatal Medicine

Mjesto i datum
Atena, Grčka, 13.10.2004. - 16.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
chorionic villus sampling; prenatal diagnosis

Sažetak
AIM:This study comprises data from 4000 women allocated to transcervical CVS (TC-CVS), transabdominal CVS (TA-CVS) and transvaginal CVS (TV-CVS). We have assessed the efficacy of transabdominal CVS compared with transcervical CVS and transvaginal CVS, and examined factors that have been implicated in causing spontaneous abortion. METHODS: Over a twelve year’ s period 4000 women underwent chorionic villus sampling at 9-12 weeks of gestation, by transcervical, (550 patients) transabdominal (3350 patients) and transvaginal technique (100 patients). Transvaginal color Doppler was used to investigate the uteroplacental and fetal vessels in 500 pregnancies between 11 and 12 weeks of gestation (400 TA-CVS and 100 TC-CVS) before and after CVS procedures. RESULTS: 550 (13, 7 %) patients underwent transcervical CVS (TC-CVS) and spontaneous abortion after TC-CVS occurred in five cases (0, 9 %). 33500 (83, 8 %) patients underwent transabdominal CVS (TA-CVS) using a 20 gauge spinal needle and abortion after TA-CVS occurred in eleven cases (0, 33 %). One hundred (2, 5 %) patients underwent transvaginal CVS (TV-CVS) using a 20-gauge needle and abortion after TV-CVS occurred in three cases (3, 0 %). The spontaneous abortion rate after CVS procedures was 0, 48 %. 124 (3, 1 %) cases showed chromosomal aberration. The spontaneous abortion rate was lower among cases allocated to TA-CVS after 11 weeks of gestation. There were no significant differences in mean pulsatility indices (PI) between maternal, fetal and intraplacental circulation, before and after CVS procedures. CONCLUSION: Transabdominal CVS has lower fetal loss rate than transcervical and transvaginal CVS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA