Uric acid inhibits glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic b-cells

Ročić, Boris; Vučić Lovrenčić, Marijana; Poje, Nevenka; Poje, Mirko; Bertuzzi, Federico

Pregled bibliografske jedinice broj: 179664

Uric acid inhibits glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic b-cells

Ročić, Boris; Vučić Lovrenčić, Marijana; Poje, Nevenka; Poje, Mirko; Bertuzzi, Federico

Uric acid inhibits glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic b-cells // Bioorganic & medicinal chemistry letters, 15 (2005), 4; 1181-1184 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 179664 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Uric acid inhibits glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic b-cells

Autori
Ročić, Boris ; Vučić Lovrenčić, Marijana ; Poje, Nevenka ; Poje, Mirko ; Bertuzzi, Federico

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 15 (2005), 4; 1181-1184

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
uric acid; purines; beta-cell; pancreatic islets; guanidinium urate; arginine residue; glucose-stimulated insulin secretion; uricase

Sažetak
Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets, and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (>0.4 mM). Conversely, 1 mM guanidinium urate (2a) was completely ineffective, strongly suggesting that binding to an essential arginine residue triggers the inhibitory effect. A specific recognition of 1a molecule at the crucial beta-cell receptor is probably involved in the blocking glucose signal transduction.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA

Projekti:
0119613
0045001

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Nevenka Poje (autor)