Naslov
Gluten-Free Diet Has a Beneficial Effect on Chromosome Instability in Lymphocytes of Children With Coeliac Disease

Autori
Kolaček, Sanja ; Jadrešin, Oleg ; Petković, Iskra ; Mišak, Zrinjka ; Sonicki, Zdenko ; Booth, Ian Westerby

Izvornik
Journal of pediatric gastroenterology and nutrition (0277-2116) 38 (2004), 2; 177-180

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromosome aberrations; coeliac disease; gluten-free diet

Sažetak
Objectives. Children with coeliac disease (CD) have an increased number of chromosome aberrations in peripheral blood lymphocytes. Whether genetically determined or a secondary phenomenon in CD, chromosome abnormalities may be involved in the predisposition to cancer in CD patients. The aim of the study was to follow a group of children with CD in whom the initial frequency of chromosome aberrations at diagnosis was known and to measure the same variable after a minimum of 2 years on a gluten-free diet. Methods. Chromosome aberrations in peripheral blood lymphocytes were determined in 17 patients with CD, before and after at least 24 months of a gluten free diet (mean, 33 months), and in 15 healthy children. The differences in the frequency of aberrations were analyzed by Mann-Whitney U test and Wilcoxon matched-pairs signed-ranks test. Results. Twelve patients adhered to the diet and had a significantly lower frequency of chromosome aberrations than did 5 patients not following the diet (0.16 v. 1.2% ; p=0.03), wheras at presentation there had been no difference (1.54 v. 1.2% ; p=0.09). The frequency of aberrations at follow-up in patients who were diet adherent patients was significantly lower than at presentation (1.54 v. 0.16% ; p=0.02) and remained unchanged in patients who were not diet adherent (1.2 v. 1.2% ; p=1). After at least 24 months of a gluten free diet, children with CD did not differ from healthy control subjects (0.16 v. 0.27% ; p=0.54), wheras children not following the diet had an increased frequency of aberrations (1.2 v. 0.27% ; p=0.05). Conclusions. The frequency of chromosome aberrations in peripheral blood lymphocytes of patients with CD decreased significantly on a gluten-free diet. We conclude that genomic instability is a secondary phenomenon, possibly caused by chronic intestinal inflammation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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