Naslov
Interrelated effects of high surcose diet and gemfibrozil on buthyrylcholinesterase activity and plasma lipids in rats

Autori
Bradamante, Vlasta ; Vrkić, Nada ; Lucić, Ana ; Radić, Božica ; Macan, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum Biologorum. Vol. 16, suppl. 1 (2004) / Vitale, Branko - Zagreb, 2004, 110-110

Skup
Fourth Croatian Congress of Pharmacology

Mjesto i datum
Split, Hrvatska, 15.09.2004. - 18.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Buthyrylcholinesterase; triglycerides; gemfibrozil; plasma lipids

Sažetak
Introduction. Butyrylcholinesterase (BuChE), also known as pseudocholinesterase, is produced in the liver and secreted into the circulation. The biological function of BuChE is unknown, but many results show that it is probably involved in serum lipid metabolism. BuChE was found to be elevated in patients with hyper-lipoproteinemia or hypertriglyceridemia, and that streptozotocin- induced diabetic mice have shown increased plasma BuChE activity concomitant with increased plasma triglycerides (TG). Iso-OMPA, a non-toxic inhibitor of plasma BuChE, reduces plasma and liver TG and plasma very-low density lipoproteins (VLDL) in streptozotocin-induced rodent diabetes. Diet rich in sucrose increases the synthesis and secretion of VLDL by the liver and induces hypertriglyceridemia in man and experimental animals. Thus, it could be presumed, that in rats fed with a high carbohydrate diet, the resulting hypertriglyceridemia increases BuChE activity, and that treatment with gemfibrozil (GEM), causes the decrease of plasma TG and BuChE activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA