Naslov
Prognostic significance of CD44 molecule in renal-cell carcinoma

Autori
Lučin, Ksenija ; Matušan, Koviljka ; Đorđević, Gordana ; Stipić, Darko

Izvornik
Croatian Medical Journal (0353-9504) 45 (2004), 6; 703-8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD44S antigen; CD44v5 antigen; CD44v6 antigen; prognosis; immunohistochemistry; cell adhesion

Sažetak
Aim. To analyze the expression and the prognostic value of CD44s and variant v5, and v6 isoforms, in large series of conventional renal-cell carcinomas. Methods. The expression of CD44 isoforms was immunohistochemically evaluated in 173 conventional renal-cell carcinomas, and was compared to usual clinicopathological parameters such as tumor size, histological grade, pathological stage, and Ki-67 proliferative index. The relationship of the CD44 expression to the cancer-specific survival was evaluated by log rank test. Results. While normal renal tissue was negative for CD44s protein, it was upregulated in 70 (40.5%) out of 173 carcinomas, and its expression significantly correlated with histological grade (p<0.001), pathological stage (p=0.023) and Ki-67 proliferative index (p<0.001). Moreover, the expression of CD44s protein was found to be adverse prognostic parameter in univariate survival analysis for patients with tumors expressing high levels of CD44s protein (p=0.003). CD44v5 and v6 isoforms were expressed in 11 (6.4%) and 28 (16.2%) tumors, respectively. Their expression was significantly higher in tumors with higher histological grade (p=0.001 and p=0.001, respectively). Also, the expression of v6 isoform was higher in tumors with high proliferation activity (p=0.001). Conclusion. CD44s molecule may play a role in the progression of conventional renal-cell carcinoma, and may be used in evaluation of outcome of disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA