Naslov
Spectroscopic studies of methylglyoxal in water and dimethylsulfoxide
(Spectroscopic Studies on Methylglyxal in Water and Dimethylsulfoxide)

Autori
Nemet, Ina ; Vikić-Topić, Dražen ; Varga-Defterdarović, Lidija

Izvornik
Bioorganic chemistry (0045-2068) 32 (2004), 6; 560-570

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Methylglyoxal ; 1 ; 1-Dimethoxypropanone ; Methylglyoxal polymers

Sažetak
Methylglyoxal is a highly reactive dicarbonyl compound, which in vivo spontaneously reacts with biological macromolecules thus affecting their structure and functions. These changes are associated with complications during aging, diabetes and Alzheimer's disease as well as with growth inhibition in different tumors. Many enzymes are involved in the metabolism of methylglyoxal, but its real role in the metabolic network and its chemical properties are still obscure. In this study it was shown that methylglyoxal, during the freeze-drying of aqueous solutions, polymerizes into small polymeric structures which are stable in organic media such as dimethylsulfoxide. When reexposed to water, the polymers immediately transformed into the monomeric mono- and dihydrate of methylglyoxal. By NMR and UV spectroscopy, it was shown that solvent, temperature, and the amount of available water strongly influence the equilibrium of the different forms of methylglyoxal and thereby change its reactivity. 1H and 13C NMR spectroscopy were used to determine the structures of the different monomeric and oligomeric structures of methylglyoxal.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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