Naslov
The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice

Autori
Bach-Rojecky, Lidija ; Kalođera, Zdenka ; Samaržija, Ita

Izvornik
Acta pharmaceutica (1330-0075) 54 (2004), 2; 157-162

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Hypericum perforatum L. (Hypericaceae); antidepressant effect; forced swimming test; tail suspension test

Sažetak
The pharmacological approach to the treatment of depression includes a long-term employment of antidepressants, either in the form of monotherapy or as a combination of several antidepressant with various mechanism of action. Hypericum perforatum L. (St. John's wort) is the only natural antidepressant. Several constituents of the extract, such as hypericin and hyperforin, seem to be important for this effect. H. perforatum is considered to be an effective alternative to other therapeutic agents in the treatment of mild to moderate depression. The paper describes the investigation of the antidepressant effect of H. perforatum (doses 7, 35 and 70 mg kg-1 b.m.) on mice using the forced-swimming and tail-suspension methodes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA