Naslov
Cytogenetic characteristics of childhood lymphoma

Autori
Petković, Iskra ; Nakić, Melita ; Konja, Josip ; Petković, Giorgie

Izvornik
Liječnički vjesnik (1330-4917) 125 (2003), Suppl.3.;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Cytogenetic characteristics of childhood lymphoma

Sažetak
The aim of this investigation was to define the frequency and types od acquired clonal chromosomal abnormalities in our group of childhood non-Hodgkin's lymphoma. Our investigation included 16 children, aged from 9 months to 15 years. Cytogenetic analysis of malignant cells was carried out at the time diagnosis was made, before initiating therapy. Slides were obtained from short-term culture of lymph node or bone marrow cells. Chromosome identification was carried out using G-banding method.Cytogenetic analysis revealed clonal chromosomal abnormalities in 11 (68.7%)out of 16 children. Chromosome instability and evidence of clonal evolution were observed in 3 patients. Pseudodiploid clone was observed in 4, hyperdiploid in 5 and hypotriploid in 2 out of 11 children with clonal chromosomal aberrations. This investigation revealed complex numerical and structural aberrations. The gains of some chromosome types were nonrandom and frequently affected chromosomes were 11, 14, 21 and X. Involvement of particular chromosome type in structural abnormalities was nonrandom too. The rearrangement involving chromosome No.1 and No. 14 were observed in 5 and 4 cases respectively. This investigation confirms variability of clonal chromosomal aberrations and cytogenetic heterogeneity of childhood non-Hodgkin lymphomas. Additional investigations are however, necessary to define more precisely the frequency and types of aberrations, and biological role of chromosomal regions in the development of NHL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA