Naslov
Gene nm23-H1 - possible prognostic factor for invasive squamous cell carcinoma of cervix uteri

Autori
Ilijaš, Marijan ; Kapitanović, Sanja ; Šarčević, Božena ; Pavelić, Krešimir ; Pavelić, Zlatko Paul ; Kurjak, Asim ; Pavelić, Jasminka

Izvornik
Journal of Tumor Marker Oncology (0886-3849) 13 (1998), 3; 61-67

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nm23-H1; prognostc factor; squamous cell carcinoma; cervix uteri

Sažetak
Data are presented on nm23-H1 protein presence in human invasive squamous cell carcinoma of the cervix, and its relationship to clinical signs of disease progression (metastases development, local disease reccurrence, 5-year survival) and FIGO stage of disease. Protein expression was examined on 152 formalin fixed, paraffin embedded tumor samples using immunohistochemical peroxidase antiperoxidase method. in general, the number of nm23-H1 positive tumors among FIGO stages Ib (2), IIa/b, IIIb and IVa, regardless of survival rate, declined. Reccurence of local disease and distant metastases development were predominantly recorded in patients with nm23-H1 negative tumors. The difference in 5-year survival of patients with nm23-H1 positive versus negative tumors is obvious and statistically significant at the level of (p<0.01). According to our results, regularly treated patients suffering from nm23-H1 negative tumors exhibit in a higher percentage (statistically significant) local relapse illness, distant metastases development and shorter survival. Our results clearly show correlation between nm23-H1 expression and both, patients survival and disease stage. This suggests that nm23-H1 gene plays a very important role in growth control and metastases development and may serve as prognostic marker for patients with squamous cell carcinoma.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA