Naslov
Secondary Osteoporosis in Patient with Adult Celiac Disease

Autori
Sinčić Mijandrušić, Branka ; Crnčević Orlić, Željka ; Jurišić Eržen, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstracts of the 29th European Symposium on Calcified Tissues ; u: Calcified Tissue International 70 (2002) (4) P-92 / Civitelli, Roberto ; Hruska, Keith ; Ralston, Stuart - Lyon : Springer, 2002, 282-282

Skup
European Symposium on Calcified Tissues (29 ; 2002)

Mjesto i datum
Zagreb, Hrvatska, 25.05.2002. - 29.05.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
secondary osteoporosis; celiac disease

Sažetak
Bowel diseases are frequently associated with bone loss. We have analyzed a fifty two year old woman who came to the clinic with the ilness history of diarrhea, loss of weight and old fracture of fourth left metacarpal bone. Routine laboratory test indicated malapsorption problems. Results of D-xylosa test, lipid absorption test, endomisial antibodies and jejunal biopsy confirmed the diagnosis of celiac disease. After the specific diet treatment she slowly gained weight, but body mass index (BMI) did not rise more than 20 kg/m2.After she was complaining of back pain, x-ray examination and bone densitometry were done. Low bone mineral density (BMD) values indicated osteoporosis. Biochemical markers of bone resorption confirmed an active resorption phase of bone remodeling. Parathyroid hormone (PTH) was twice the normal values. Bone biopsy and hystomorphometry established the diagnosis of hyperparathyroidism. After three mounths of treatment with biosposphonates (alendronate), vitamin D and calcium supplementation, bone markers were elevated and the patient complained less of back pain. The findings of the present case report suggest that patients with malapsorption syndrome are at high risk for bone loss. Further studies are needed to evaluate the efficacy of specific antiresorptive therapies and clinical utility of biochemical markers of bone turnover in predicting therapeutic response in these patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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