Naslov
CLASSICAL AND MICROWAVE-ASSISTED SYNTHESIS AND SPECTROSCOPIC ANALYSIS OF SOME PYRAZOLE DERIVATIVES

Autori
Jukić, Marijana ; Rapić, Vladimir ; Vikić-Topić, Dražen ; Vorkapić Furača, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts: ESOC , 2003. P1-42 / - Zagreb, 2003, 169-169

Skup
13th European Symposium on Organic Chemistry

Mjesto i datum
Dubrovnik, Hrvatska; Cavtat, Hrvatska, 10.09.2003. - 15.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
pyrazole derivatives; spectroscopic analysis; microwave-assisted synthesis

Sažetak
In continuation of our studies in the field of N- containing heterocycles1, 2 we decided to examine cyclizations of hydrazines with polyketones. Some of these well-known methods have been recently performed by microwaves irradiation (MW)3. Here we report on acid catalyzed reactions of triketone (1, Ar = p-tolyl) with Ar?NHNH2 (Ar? = phenyl, p- nitrophenyl) in ethanol in comparison with the transformations achieved by MW technique without solvent. By heating of an ethanolic solution of 1 with p-nitrophenylhydrazine pyrazol-hydrazone 2 accompanied with addition intermediate were obtained. Under the similar conditions phenylhydrazine hydrochloride gave 3, 4 and several unidentified byproducts. The short MW irradiation of the same reaction mixture without solvent resulted in formation of 3. The structures of the obtained compounds were determined by 1D and 2D homo- and heteronuclear NMR techniques.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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