Naslov
NK cell activation through the NKG2D ligand mult-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene M145

Autori
Krmpotić, Astrid ; Hasan, Milena ; Loewendorf, Amdrea ; Saulig, Tanja ; Halenius, Anne ; Lenac, Tihana ; Polić, Bojan ; Bubić, Ivan ; Kriegeskorte, Anja ; Pernjak-Pugel, Ester ; Messerle, Martin ; Hengel, Hartmut ; Busch, Dirk H. ; Koszinowski, Urlich H. ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Knjiga sažetaka: Annual Meeting of the Croatian Immunological Society 2004. / Jonjić, Stipan ; Gagro, Alenka ; Polić, Bojan - Rijeka, 2004

Skup
Annual Meeting of the Croatian Immunological Society 2004.

Mjesto i datum
Opatija, Hrvatska, 08.10.2004. - 10.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
NK Cell

Sažetak
Mouse NK cell activating receptor NKG2D interacts with three different cellular ligands, all of which are regulated by mouse cytomegalovirus (MCMV). We set out to define the viral gene product regulating MULT-1, a newly described NKG2D ligand and found that MCMV infection strongly induces MULT-1 gene expression, but surface expression of this glycoprotein is nevertheless completely abolished by the virus. Screening a panel of MCMV deletion mutants defined the gene m145 as the viral regulator of MULT-1. The MCMV glycoprotein encoded by m145 gene turned out to be necessary and sufficient to regulate MULT-1 by preventing plasma membrane residence of MULT-1. The importance of MULT-1 in NK cell regulation in vivo was confirmed by the attenuating effect of the m145 deletion which was lifted after NK cell depletion. Our findings underline the significance of escaping MULT-1/NKG2D signaling for viral survival and maintenance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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