Naslov
Endocrine disrupting xenobiotics - implications in reproductive system
(Endocrine Disrupting Xenobiotics-Implications in Reproductive System)

Autori
Šimić, Branimir ; Kniewald, Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of the "3rd Croatian Congress of Toxicology - CROTOX 2004", Plitvice Lakes, Croatia, May 26-29, 2004 / - Zagreb : Hrvatsko toksikološko društvo, 2004

Skup
3rd Croatian Congress of Toxicology-CROTOX 2004

Mjesto i datum
Plitvička Jezera, Hrvatska, 26.05.2004. - 29.05.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
reproductive systeme; lindane; endocrine disrupter; androgen metabolism; spermatogenesis

Sažetak
There is growing concern on possible harmful consequences of exposure to xenobiotics that are capable of modulating or disrupting the endocrine system. The increasing evidences of various problems and abnormalities in human and wildlife reproductive health support the hypothesis that chemicals in the environment are causes of these endocrine mediated adverse effects. Alteration of endocrine functions caused by endocrine disruptors may be through interference with the synthesis, secretion, transport, binding to specific receptors, or metabolism and elimination of endogenous hormones in the organism that are responsible for maintanance of homeostasis and reproductive capability. Xenobiotics in the environment can be endocrine disruptors that mimic, enhance or inhibit the action of hormones. Dose, body burden, frequency and duration of exposure at critical periods of life are important consideratios for assessing adverse effects of pressumed endocrine disruptor. Numerous natural compounds, industrial chemicals, as well as pesticides of various classes (certain insecticides, herbicides and fungicides) are confirmed to posses the abbilities of interference with the endocrine system.This presentation is not intended to address all components of the endocrine system, neither all confirmed or predicted xenobiotics that might be involved in disruption of physioilogical processes in the organism. Our investigations might give the additional insight in possible harmfull effects of organochlorine insecticide lindane on male reproductive system. Changes in hormone-dependent tissues (pituitary, prostate and testis) under the lindane influence were followed. Alterations in androgen metabolism and interaction with specific receptors in target tissues, as well as the modification of spermatogenesis with intracellular changes in testes were detected.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA