Naslov
Comparative randomized pilot study of azithromycin and doxycycline efficacy and tolerability in the treatment of prostate infection caused by Chlamydia trachomatis

Autori
Krhen, I. ; Škerk, V. ; Lisić, M. ; Begovac, J. ; Roglić, S. ; Škerk, V. ; Ljubin-Sternak, S. ; Banaszak, A. ; Strugar-Šuica, J. ; Vuković, J. ; Milošević, V.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings Fifth Meeting of the European Society for Chlamydia Research / - Budimpešta, 2004

Skup
Proceedings Fifth Meeting of the European Society for Chlamydia Research

Mjesto i datum
Budimpešta, Mađarska, 01.09.2004. - 04.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Azithromycin; doxycycline; prostate infection; Chlamydia trachomatis

Sažetak
A total of 125 patients were examined, older than 18 years of age, with symptoms of chronic prostatitis and presence of Chlamydia trachomatis confirmed by DNA/RNA hybridization method and/or by isolation on McCoy culture and by immunofluorescent typing with monoclonal antibodies in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage. The patients were randomized in ratio 2/1 ; azithromycin/doxycycline, to receive a total of 4, 0 g azithromycin for 4 weeks, given as a single, 1-day therapy of 1 x 1000 mg weekly for 4 weeks or doxycycline 100 mg b.i.d. for 28 days. Patient`s sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. In the group of patients with chlamydial infection of prostate, the eradication rates (azithromycin 65/82, doxycycline 33/43 ; p=0, 82) and the clinical cure rates (azithromycin 56/82, doxycycline 30/43 ; p=0, 94) were not significantly different with regards to the administered drug.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA