Naslov
Atypical disseminated canine histoplasmosis - a case report

Autori
Džaja, Petar ; Grabarević, Željko ; Rakočević, Silvija ; Gudan, Andrea ; Beck, Ana ; Smolec, Ozren ; Sabočanec, Ružica

Izvornik
Veterinarski arhiv (0372-5480) 74 (2004), 2; 165-173

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
histoplazma capsulatum ; disseminated histoplasmosis ; dog ; Croatia

Sažetak
The paper describes a case of disseminated histoplasmosis in a 13-year-old female, mixed-breed dog, which was suffered from severe atopyc dermatitis which was treated with prednisolone. Blood laboratory evaluation showed anaemia, decreased hemoglobin level, decreased PCV, and blood smear examination revealed lymphopenia and neutrofilic left shift. Because of the poor health condition the animal was euthanised and necropsy was performed at our department. Macroscopically, deep hemorrhagic bilateral necrosis on both coxal tubers, miliary necroses dispersed through the liver, severe subcutaneous oedema and diffusely enlargement of spleen and lymp nodes were found. Tissue samples for histopathological examination were stained using hematoxiline-eosine method, PAS stain and Grocott's methamine silver method for fungi. Histopathological examination of skin lesion, liver, spleen and lymph nodes revealed numerous enlarged histiocytes infiltrated with inztracytoplasmatical oval, 2-4 μ m large yeastlike bodies. This intramacrophagic yeast was identified as fungus Histoplasma capsulatum and to our knowledge this is the first case of histoplasmosis in Croatia. The way of infection was very likely transepidermal through preexisting skin lesions caused by atopy, because the lungs and intestines were without any sign of histoplasmosis.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

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