Pregled bibliografske jedinice broj: 159883
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides // Tetrahedron, 60 (2004), 6225-6231 (međunarodna recenzija, članak, znanstveni)
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Naslov
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides
Autori
Piantanida, Ivo ; Palm, Barbara S. ; Čudić, Predrag ; Žinić, Mladen ; Schneider, Hans-Jorg
Izvornik
Tetrahedron (0040-4020) 60
(2004);
6225-6231
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Bis-phenanthridinium; Intercalation; DNA; RNA.
Sažetak
The acyclic bis-phenanthridinium ligands 1, 2 and the cyclic analogue 3 bind to ss-RNA by bis-intercalation. Due to it's shorter linker 1 exhibits mono-intercalative binding to ds-polynucleotides, while a mixed mode of binding with 2 is shown to strongly dependent on the base composition and tertiary structure of ds-DNA and RNA. The cyclic analogue 3 binds to ds-polynucleotides by non-intercalative mode. Comparing the ss-/ds-polynucleotide selectivity obtained for 3 and previously reported for 3, 8-linked bis-phenanthridinium analogues, it is clear that the more rigid structure and sterically more restricted cleft of the latter could better distinguish ss- from ds-polynucleotide regions.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- Biological Abstracts
- Chemical Abstracts
