Pregled bibliografske jedinice broj: 156159
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma // Annals of the New York Academy of Sciences, 1030 (2004), 1; 134-143 doi:10.1196/annals.1329.017 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 156159 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma
Autori
Levanat, Sonja ; Musani, Vesna ; Komar, Arijana ; Orešković, Slavko
Izvornik
Annals of the New York Academy of Sciences (0077-8923) 1030
(2004), 1;
134-143
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Hedgehog/patched signaling ; SHH ; SMO ; GLI1 ; PTCH ; PTCH polymorphisms ; ovarian fibromas ; ovarian dermoids
Sažetak
We compared the expression of target genes of Hedgehog/patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibromas and dermoids.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
