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Pregled bibliografske jedinice broj: 156132

Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids

Barbarić, Monika; Uršić, Stanko; Pilepić, Viktor; Zorc, Branka; Hergold-Brundić, Antonija; Nagl, Ante; Grdiša, Mira; Pavelić, Krešimir; Snoeck, Robert; Andrei, Graciela et al.
Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids // Journal of medicinal chemistry, 48 (2005), 884-887 doi:10.1021/jm040878r (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 156132 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids

Autori
Barbarić, Monika ; Uršić, Stanko ; Pilepić, Viktor ; Zorc, Branka ; Hergold-Brundić, Antonija ; Nagl, Ante ; Grdiša, Mira ; Pavelić, Krešimir ; Snoeck, Robert ; Andrei, Graciela ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Izvornik
Journal of medicinal chemistry (0022-2623) 48 (2005); 884-887

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hydroxamic acids ; cytostatic evaluation ; antiviral evaluation ; crystalography

Sažetak
In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrates that the compounds 2b, d, e and g exhibited rather marked inhibitory activity (IC50 = 7-10 uM) against malignant tumor cell lines: colon carcinoma (SW620), laryngeal carcinoma (Hep2), pancreatic carcinoma (MiaPaCa2). Compound 2e showed the most pronounced anti-CMV activity (EC50 = 1.5 and 0.8 ug mL-1) only at ≥ 5-fold lower than the cytotoxic concentration. Compounds 2d and 2f showed modest, albeit selective activity against cytomegalovirus (2d: EC50 = 7.3-8.9 ug mL-1, selectivity index 7-10, and 2f: EC50 = 7-13 ug mL-1 and selectivity index 10).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
0098093
0006431
0006543
0125003

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Monika Barbarić (autor)

Avatar Url Antonija Hergold-Brundić (autor)

Avatar Url Viktor Pilepić (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Stanko Uršić (autor)

Avatar Url Mirica Grdiša (autor)

Avatar Url Krešimir Pavelić (autor)

Poveznice na cjeloviti tekst rada:

doi pubs.acs.org doi.org

Citiraj ovu publikaciju:

Barbarić, Monika; Uršić, Stanko; Pilepić, Viktor; Zorc, Branka; Hergold-Brundić, Antonija; Nagl, Ante; Grdiša, Mira; Pavelić, Krešimir; Snoeck, Robert; Andrei, Graciela et al.
Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids // Journal of medicinal chemistry, 48 (2005), 884-887 doi:10.1021/jm040878r (međunarodna recenzija, članak, znanstveni)
Barbarić, M., Uršić, S., Pilepić, V., Zorc, B., Hergold-Brundić, A., Nagl, A., Grdiša, M., Pavelić, K., Snoeck, R. & Andrei, G. (2005) Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids. Journal of medicinal chemistry, 48, 884-887 doi:10.1021/jm040878r.
@article{article, author = {Barbari\'{c}, Monika and Ur\v{s}i\'{c}, Stanko and Pilepi\'{c}, Viktor and Zorc, Branka and Hergold-Brundi\'{c}, Antonija and Nagl, Ante and Grdi\v{s}a, Mira and Paveli\'{c}, Kre\v{s}imir and Snoeck, Robert and Andrei, Graciela and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2005}, pages = {884-887}, DOI = {10.1021/jm040878r}, keywords = {hydroxamic acids, cytostatic evaluation, antiviral evaluation, crystalography}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm040878r}, volume = {48}, issn = {0022-2623}, title = {Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids}, keyword = {hydroxamic acids, cytostatic evaluation, antiviral evaluation, crystalography} }
@article{article, author = {Barbari\'{c}, Monika and Ur\v{s}i\'{c}, Stanko and Pilepi\'{c}, Viktor and Zorc, Branka and Hergold-Brundi\'{c}, Antonija and Nagl, Ante and Grdi\v{s}a, Mira and Paveli\'{c}, Kre\v{s}imir and Snoeck, Robert and Andrei, Graciela and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2005}, pages = {884-887}, DOI = {10.1021/jm040878r}, keywords = {hydroxamic acids, cytostatic evaluation, antiviral evaluation, crystalography}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm040878r}, volume = {48}, issn = {0022-2623}, title = {Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids}, keyword = {hydroxamic acids, cytostatic evaluation, antiviral evaluation, crystalography} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Chemical Abstracts

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