Naslov
Pre-treatment platelet serotonin concentration and response to paroxetine treatment

Autori
Pivac, Nela ; Muck-Šeler, Dorotea ; Mustapić, Maja ; Šagud, Marina ; Mihaljević-Peleš, Alma ; Jakovljević, Miro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 4th Congress of the Federation of the European Pharmacological Societies (EPHAR) ; u: Fundamental and Clinical Pharmacology 18 (2004) (S1) ; Posters 23–126 ; P 05.34 / Bousquet, Pascal ; Zannad, Faiez - Oxford : Wiley-Blackwell, 2004, 45-45

Skup
Congress of the Federation of the European Pharmacological Societies (4 ; 2004)

Mjesto i datum
Porto, Portugal, 17.07.2004. - 19.07.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pre-treatment platelet 5-HT concentration; good therapeutic response; antidepressants; paroxetine; depression

Sažetak
The disturbance of the serotonergic system is assumed to be involved in the pathogenesis of depression. Blood platelets are used as a peripheral model for the central serotonergic synaptosomes, since they are able to take up, store and release serotonin (5-hydroxytryptamine, 5-HT). Aim: The aim of the study was to determine if pre-treatment values of platelet 5-HT concentration might predict the good therapeutic response to antidepressant paroxetine. Treatment response was determined as 50% fall in Hamilton Rating Scale for Depression (HAMD) scores from baseline. Platelet 5-HT concentration was determined at baseline (before treatment), and after 4-5 weeks of treatment with paroxetine (selective serotonin reuptake inhibitor, SSRI), in 50 nonsuicidal, nonpsychotic female patients with major depression (DSM-IV criteria), and compared with values in 77 drug free healthy women. Results: Before treatment platelet 5-HT concentration differed significantly between 34 responders and 16 non-responders. The pre-treatment values of platelet 5-HT concentration were significantly higher in non-responders than in responders, or than in corresponding healthy subjects. As expected, platelet 5-HT concentration was similarly decreased after treatment in both responders and non-responders. Conclusion: In the search for the possible predictor of the therapeutic outcome, our preliminary data suggest that decreased baseline platelet 5-HT concentration found in responders might be used as an indicator of the good therapeutic response to 4-5 weeks of treatment with paroxetine in female depressed patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
DOI: 10.1111/j.1472-8206.2004.00261.x

POVEZANOST RADA