Naslov
Synthesis of the novel bicyclic oxepinopyrimidine and fluorinated pyrrolidinopyrimidines

Autori
Batinac, Sanja ; Mrvoš Sermek, Draginja ; Cetina, Mario ; Pavelić, Krešimir ; Mintas, Mladen ; Raić-Malić, Silvana

Izvornik
Heterocycles (0385-5414) 63 (2004), 11; 2523-2536

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5 ; 6-dialkylated pyrimidine derivatives ; bicyclic pyrimidines ; X-ray crystal structure

Sažetak
The new 5, 6-disubstituted pyrimidine nucleoside analogues (5-8) were synthesized by addition of the C-6 lithiated pyrimidine derivative to oxirane as key reaction step. The bicyclic tetrahydrooxepinopyrimidine (9) and fluorinated pyrrolidinopyrimidines (12 and 15) were obtained by intramolecular linkage of acyclic chain to the CH2-5 and N-1 of the pyrimidine ring. The structure of compound (9) containing pyrimidine and tetrahydrooxepine skeleton was determined unequivocally by its X-Ray crystal structure analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Rad je objavljen i u ChemInform (0931-7597) 36 (2015)(15) ; https://onlinelibrary.wiley.com/doi/full/10.1002/chin.200515198 ; https://doi.org/10.1002/chin.200515198

POVEZANOST RADA