Naslov
Congenital Syphilis Associated with Hyperlipoproteinemia

Autori
Meštrović, Julije ; Krželj, Vjekoslav ; Balarin, Livio ; Meštrović, Marija ; Škrabić, Veselin

Izvornik
Pediatric dermatology (0736-8046) 14 (1997), 3; 226-228

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Sažetak
An infant with congenital syphilis associated with transient disturbances of lipoprotein metabolism is reported. The dominant clinical sign was hepatosplenomegaly. Laboratory investigation upon admission revealed hyperimmunoglobulinemia and hyperchylomicronemia. After the administration of penicillin, the hyperchylomicronemia ceased, but an increase of very low density lipoprotein fraction was observed. As the infant recovered, all the laboratory findings returned to normal. Hyperchylomicronemia was attributed to hyperimmunoglobulinemia. Absorption of immnoglobulins to lipoproteins can inhibit lipoprotein lipase activity. The increase in the very low density lipoprotein fraction was probably caused by the increase in serum lipoprotein production and the decrease in lipoprotein clearence that are frequently seen in patients with infectious disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA