Naslov
Molecular modelling of bioactive gluten peptides and related T-cell receptors

Autori
Štambuk, Nikola ; Tješić-Drinković, Duška ; Votava-Raić, Ana ; Konjevoda, Paško ; Tješić-Drinković, Dorian ; Mađerčić, Lana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts MATH/CHEM/COMP 2004 / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko - Zagreb : Institut Ruđer Bošković, 2004, 79-79

Skup
MATH/CHEM/COMP 2004 - The 19th Dubrovnik International Course & Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 21.06.2004. - 26.06.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
binding motif; celiac disease; gluten; HLA DQ2; molecular modelling; molecular recognition theory; peptide; T-cell receptor

Sažetak
Celiac disease is a common autoimmune condition caused by a selective lack of T cell tolerance for gluten. We investigated an algorithm for the prediction of T cell stimulatory gluten peptides. The combined molecular modelling approach is based on the use of HLA DQ2 peptide binding motifs, the specificity of residues for tissue transglutaminase, and the reconstruction/prediction of the interacting T-cell receptor sequence by means of the Molecular Recognition Theory. Modelled bioactive peptide sequence was XQXPQXP and its predicted T-cell receptor target motif was heptapeptide PVHGVRG.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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