Naslov
Induction of p53 in mussel Mytilus galloprovincialis tissues

Autori
Jakšić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
37th CIESM Congress Proceedings / CIESM - Barcelona : CIESM, 2004

Skup
37th CIESM Congres

Mjesto i datum
Barcelona, Španjolska, 07.06.2004. - 11.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biomonitoring; ecotoxicology; genotoxic agents; musell Mytilus galloprovincialis; p53

Sažetak
The tumor suppressor phosphoprotein p53 as a biomarker of genotoxic stress in marine mussel Mytilus galloprovincialis were investigated. The effect of direct and indirect acting genotoxic xenobiotic compounds on p53 protein family levels were determinated using the Western blot analysis and immunoassay detection. The well known DNA damaging agents: N-methil-N´-nitro-nitrosoguanidine (MNNG), 4-nitroquinoline-N-oxide (NQO), and benzo[a]pyrene (B[a]P) induced level of p53 in a time and dose dependent manner. The aim of the study was to establish the applicability of the p53 induction as a genotoxic stress estimation tool and promised use of p53 as a biomarker in marine ecotoxicological monitoring research.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Biologija

POVEZANOST RADA