Naslov
Monoamine Oxidases A and B Gene Polymorphisms in Migraine Patients

Autori
Filić, Vedrana ; Vladić, Anton ; Štefulj, Jasminka ; Čičin-Šain, Lipa ; Balija, Melita ; Sučić, Zvonimir ; Jernej, Branimir

Izvornik
Journal of the neurological sciences (0022-510X) 228 (2005), 2; 149-153

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
migraine ; monoamine oxidase ; polymorphism ; serotonin ; noradrenaline ; platelet

Sažetak
Abnormal cortical activity and brainstem functioning are considered the possible etiopathogenetic factors of migraine. Monoamine oxidase A and B (MAO-A and B) regulate the levels of monoamine neurotransmitters, so changes in their activity could participate in migraine pathogenesis. We have investigated the possible association of MAO-A and B alleles and haplotypes with two common types of migraine, i.e. migraine without aura (MO) and migraine with aura (MA), on the sample of 110 migraineours (80 MO and 30 MA) and 150 controls. MAO-A promoter and MAO-B intron 13 polymorphisms were genotyped by the PCR based methods. In addition, we have reevaluated the reported association between MAO-B intron 13 and polymorphism and platelet activity. The platelet MAO-B activity was determined fluorimetrically using kynuramine as a substrate. We have found a tendency toward associationof the shorter variant of MAO-A gene promoter with migraine without aura. Regarding investigated MAO-B polymorphism, no association with migraine nor with platelet MAO-B activity was found. The suggestive association of the variant in MAO-A gene with migraine is considered worthy of independent replication. On the other hand, further studies on MAO-B polymorphism in migraine do not seem promising.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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