Naslov
Medium-Chain Triacylglycerols Effect Fatty Acid Modification in Rat's Kidney

Autori
Glavaš-Obrovac, Ljubica ; Steiner-Biočić, Ivka ; Delaš, Ivančica ; Popović, Milivoj

Izvornik
Croatica chemica acta (0011-1643) 69 (1996), 1; 353-362

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
short time medium-chin tryacilglycerols diet; lipids; fatty acid composition; kidney

Sažetak
The aim of this investigations was to study the effect of a short time medium-chain triacylglycerols diet (MCTD) on the lipids (particularly of fatty acids) of the rat kidney. During 14 days, two groups of rats (Fischer strain) were fed a MCTD (18.7% MCTs, 16.5 kJ/g dry matter) or an isoenergetic control diet (standard rat chow). Total lipids were isolated and separated into particular lipid classes by thin-layer chromatography. No essential differences in the distribution of analyzed lipids (cholesterol, cholesterol ester, tracylglycerols, free fatty acids, phosphatidylcholine, phosphatidylethanolamine and sphingomyeline) were noticed after MCTD. The results showed no changes in the concentration of total neutral lipids, but slight changes appeared in the concentration of particular classes of neutral lipids. Concentrations of cholesterol and cholesterol ester were decreased by approximately 14% by MCTD feeding and, at the same time, the concentration of triacylglycerols, free fatty acids and esters of fatty acids was increased by 4%. The ratio of free cholesterol to total phospholipids (C/P) decreased (17%) after MCTD. The data indicate a significant increase in fatty acid saturation (expressed asa saturation factor (S-f)) affected by MCTD. Both of the mentioned data (C/P ratio, Sc), as well as' some additional ones reported in this paper, suggest that MCTD can affect the membrane fluidity, although at present it is not possible to judge whether or not such effects could change the physiological function of the kidney.

Izvorni jezik
Engleski

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