Naslov
Pyridinium, imidazolium, and quinucludinium oximes : synthesis, interaction with native and phosphylated cholinesterases, and antidotes against organophosphates

Autori
Primožič, Ines ; Odžak, Renata ; Tomić, Srđanka ; Simeon-Rudolf, Vera ; Reiner, Elsa

Izvornik
The Journal of medical chemical defense (1540-6709) 2 (2004); 1-30

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
pyridinium ; imidazolium ; quinuclidinium oximes ; organophosphates ; cholinesterases
(pyridinium ; imidazolium ; quinuclidinium oximes ; organiophosphates ; cholinesterases)

Sažetak
This report summarizes studies on pyridinium, imidazolium, and quinuclidinium oximes, which were prepared in laboratories in Croatia since the middle of the 1970s. The prepared compounds, 176 in all, include 157 new compounds. The majority of prepared compounds are monoquaternary and bisquaternary pyridinium oximes. In vitro studies comprised reversible inhibition of cholinesterases, protection of cholinesterases from phosphylation by organophosphorus compounds (OP), and reactivation of the phosphylated enzyme. In vivo studies of the oximes as antidotes in experimental poisoning by OP compounds are also reviewed. The OP compounds were predominantly chemical warfare (CW) nerve agents but also included some related pesticides.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA