Pregled bibliografske jedinice broj: 151259
Oxygenation alters ganglioside expression in rat liver following partial hepatectomy
Oxygenation alters ganglioside expression in rat liver following partial hepatectomy // Biochemical and biophysical research communications, 330 (2005), 1; 131-141 doi:10.1016/j.bbrc.2005.02.139 (međunarodna recenzija, članak, znanstveni)
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Naslov
Oxygenation alters ganglioside expression in rat liver following partial hepatectomy
Autori
Markotić, Anita ; Čikeš Čulić, Vedrana ; Tičinović Kurir, Tina ; Meisen, Iris ; Büntemeyer, Heino ; Boraska, Vesna ; Zemunik, Tatijana ; Petri, Nadan ; Peter-Katalinić, Jasna ; Mesarić, Marko ; Müthing, Johannes
Izvornik
Biochemical and biophysical research communications (0006-291X) 330
(2005), 1;
131-141
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HPLC ; HPTLC ; immunostaining ; nanoESI-QTOF mass spectrometry ; sialic acid ; partial hepatectomy ; oxygenation ; gangliosides
Sažetak
Gangliosides from livers of weanling rats were analysed after 15% partial hepatectomy (PH) and different pre- and post-operative hyberbaric oxygenation (pre- and postHBO). Neu5Ac was the predominant ganglioside-derived sialic acid (>85%) compared to Neu5Gc. Almost identical low total sialic acid content (Neu5Ac+Neu5Gc) of the control and operated nonHBO animals opposed a 6.4 to 7.6 fold increase in pre- and postHBO animals (69.26 and 81.64 pmol per mg wet weight, respectively). NanoESI-QTOF mass spectrometry combined with HPTLC immunostaining revealed GM3(Neu5Ac) and GM3(Neu5Gc) as major gangliosides, correlating with the respective sialic acid concentrations. Minor neolacto- series gangliosides were enhanced in preHBO and postHBO, but GM1-core gangliosides only in preHBO rats. GM2 and GalNAc-GM1b were clearly detectable in oxygenated rats compared to traces in the control and nonHBO animals. These results point at a functional role of gangliosides in liver growth regulation and reconstitution after PH combined with pre- and post-operative HBO treatment.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
POVEZANOST RADA
Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište Libertas
Profili:
Nadan Petri
(autor)
Tina Tičinović Kurir
(autor)
Tatijana Zemunik
(autor)
Anita Markotić
(autor)
Vesna Boraska Perica
(autor)
Marko Mesarić
(autor)
Vedrana Čikeš Čulić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE