Naslov
Crystal structures of two 3-cyclohexanemethyl hydantoin derivatives

Autori
Cetina, Mario ; Mrvoš-Sermek, Draginja ; Nagl, Ante ; Raić-Malić, Silvana ; Zorc, Branka ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Thirteenth Slovenian-Croatian Crystallographic Meeting / Pevec, Andrej ; Meden, Anton ; Leban, Ivan - Ljubljana, 2004, 48-48

Skup
Thirteenth Slovenian-Croatian Crystallographic Meeting

Mjesto i datum
Bovec, Slovenija, 16.06.2004. - 20.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
hydantoin derivatives ; X-ray crystal structure ; hydrogen-bonding

Sažetak
Hydantoins have been used as anticonvulsive drugs and herbicides, as well as useful intermediates in the synthesis of polymer-drug conjugates. In the present study we report crystal and molecular structures of two hydantoin derivatives: 3-cyclohexanemethyl-5- isopropyl hydantoin (1) and 3- cyclohexanemethyl-5-isobutyl hydantoin (2). These two structures differ only in the side chain attached to the hydantoin ring (isopropyl in 1, isobutyl in 2), and they are conformationaly very similar. The molecules are joined by the same hydrogen-bonding motifs, involving the same donor and acceptor atoms. Thus, the intermolecular N-H• • • O hydrogen bond in 1 and 2 generates an infinite C(5) chains, and C-H• • • O intermolecular hydrogen bond forms infinite C(7) chains. These hydrogen bonds are reinforced by that of a C-H• • • O hydrogen bond in 1 and three C-H• • • O hydrogen bonds in 2, so producing two- dimensional networks. The networks are separated by hydrophobic channels in both crystal structures, but in 2, the hydrogen- bonded molecules are assembled in such manner that they form cavities along a axis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA