Naslov
Immunosuppression induced by talc granulomatosis in the rat

Autori
Radić, I. ; Vučak, I. ; Milošević, Jasminka ; Marušić, Ana ; Vukičević, Slobodan ; Marušić, Matko

Izvornik
Clinical and experimental immunology (0009-9104) 73 (1988); 316-321

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Talc; Immunosuppression; Splenectomy; Granuloma

Sažetak
Granulomatosis caused by four subcutaneous talc powder-suspension injections induced strong immunosuppression in rats.The disturbance included reduction of mononuclear white blood cell count in the peripheral blood, atrophy of the thymic cortex, spleen enlargement with predominance of red over the white pulp, increase in the number of lymph node germinal centres and a significant delay of the first-set and second-set allograft rejection.Neither phagocytic function of reticuloendothelial system nor erythrocyte count and humoral immune response were found to be altered.Indomethacin suppression of prostaglandin production did not normalize the allograft rejection dynamics.In contrast, splenectomy completely abolished the immunosuppressive effects of granulomatosis.In splenectomized, talc-treated animals WBC counts were not altered and the rejection of allografts was not delayed.Suppression of immune response to alloantigens was transferred to normal and splenectomized recipients by both serum and spleen cells of talc-injected animals.Also, in a cell mixture-transfer experiment, spleen cells from immune donors in T cell-deficient rats.The inability of serum from splenectomized talc-injected rats to transfer the suppression suggested the crucial role of the spleen in the mechanisms leading to suppression in rats bearing talc-granulomatosis

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA