Naslov
Does 1, 2-dimethyl-3-hydroxypirid-4-one (L1) mobilise mercury in rats?

Autori
Jureša, Dijana ; Varnai, Veda Marija ; Blanuša, Maja ; Kostial, Krista

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CROTOX 2004: Final Programme and Abstract Book / 3rd Croatian Congress of Toxicology (with international participation) / - Zagreb, 2004, 71-71

Skup
CROTOX 2004: 3rd Croatian Congress of Toxicology (with international participation)

Mjesto i datum
Plitvička Jezera, Hrvatska, 26.05.2004. - 29.05.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
1; 2-dimethyl-3-hydroxypirid-4-one; chelating agent; mercury

Sažetak
The chelating agent 1, 2-dimethyl-3-hydroxypirid-4-one (L1) has been used in human practice for treatment of iron overload. It also efficiently binds aluminium in the body. Its efficiency in mercury removal from the body of rats was tested and compared with efficiency of meso-2, 3-dimercaptosuccinic acid (DMSA), a chelating agent already verified to be effective for the treatment of mercury intoxication. Female Wistar rats (6 weeks old) received mercury as HgCl2 in a single intraperitoneal injection at a dose of 1.5 &micro ; ; ; mol Hg kg-1 body weight (0.30 mg kg-1). Chelating agents were given orally 30 minutes and 24 hours after mercury application at a single dose of 1.4 mmol L1 kg -1 body weight (200 mg kg-1) or 0.5 mmol DMSA kg-1 body weight (90 mg kg-1). Concentrations of mercury, copper, zinc and iron were measured in 24-hours urine collected after the first chelating agents application and in organs (liver, kidney) 72 hours after the second chelating agents application. Mercury concentration was determined using cold vapour atomic absorption spectrometry (AAS), and copper, zinc and iron concentrations were determined using electrothermal AAS. Results obtained confirmed DMSA effectiveness in lowering mercury concentrations in organs and in increasing urinary mercury excretion. L1, however, has no influence on mercury organ retention, or on urinary mercury excretion. There is no statistically significant change in organs copper, zinc and iron concentrations after chelations treatment. Urinary iron excretion is significantly increased after L1 treatment, while copper and zinc excretion are not affected. DMSA increases excretion of zinc and copper, but has no influence on iron excretion. It could be concluded that L1 cannot be used effectively in treatment of mercury intoxication.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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