Naslov
Organic-inorganic nanocomposite coatings for biomedical applications

Autori
Sikirić, Maja ; Bar-Yosef, P. ; Govrin Lippman, R. ; Garti, Nissim ; Füredi-Milhofer, Helga

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
11th Israel Materials Conference

Mjesto i datum
Haifa, Izrael, 24.12.2003. - 25.12.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
nanocomposites

Sažetak
The purpose of this research is to develop novel bone implants for load-bearing applications. One possible approach is the deposition of composite coatings, consisting of polyelectrolyte multilayers and calcium phosphate, upon different solid substrates (metals, polymers, glass ceramic). Such biocompatible multilayers should be able to trigger cell response and accelerate osteointegration. In this work we report on the adsorption of amorphous calcium phosphate, (ACP) and it’ s “ in situ” phase transformation into octacalcium phosphate (OCP) and/or calcium deficient apatites (DA) on multilayers consisting of alternating layers of poly-l-lysine and poly-l-glutamic acid. PE multilayers, consisting of poly-l-lysine (PLL) and poly-l-glutamic acid (PGA), (PLL/PGA)nPLL, (n number of layers) were deposited on formvar membranes (TEM grids) as well as glass and titanium plates. On the top of the multilayers, amorphous calcium phosphate (ACP) particles were deposited as seeds, from which calcium phosphate crystals were grown “ in situ” . The samples were observed by transmission and scanning electron microscopy and characterized by EDS and X-ray powder diffraction. The results point to a novel method to coat surfaces of implant materials by depositing organic/inorganic nanocomposite systems. By carefully designing such composite systems it should be possible to effectively trigger cell growth and biomineralization and thus speed up osteointegration

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA