Naslov
Mathematical Model of B-Cell CLL

Autori
Martinis, Mladen ; Vitale, Branko ; Zlatić, Vinko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Liječnički vjesnik 125, Supl. 3, 2003 / Čikeš, Nada - Zagreb : Hrvatski liječnički zbor, 2003, 112-112

Skup
3. hrvatski kongres hematologa i transfuziologa s međunarodnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 23.10.2003. - 26.10.2003

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
leukemia; lymphocities; B-cells

Sažetak
Chronic lymphocytic leukemia (CLL) is defined as a disorder of morphologically mature but immunologically less mature lymphocytes which is manifested by uncontrolled expansion of a single clone of B-cells that did not retain capacity to differentiate into functionally mature cells and activate the programmed cell death. Many aspects of the interaction and/or communication between B- and T-cells in CLL can be understood by examining simple nonlinear dynamical models. The significance of these models is their prognostic ability to predict, from a given initial data, the time course leading to low- or high-risk pathways of CLL.In this respect, we propose a nonlinear mathematical model of B-CLL pathogenesis in which B- CLL is considered as a clinical disorder which simultaneously affects both B-cells and T-cells on the intercellular communication level. Our dynamical model deals with a profound quantitative imbalance between expanded CD5+ME+ clone of leukemic B-cells, and only slightly increased absolute number of helper CD4+ T-cells accompanied by eight to tenfold increase of the absolute number of cytotoxic/suppressor CD8+ T- cells resulting in the inversion of the DC4/DC8 ratio to less than one in comparison with healthy subjects.The dynamics of these two active groups of cells is described by the generalized Volterra type equations.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA