Pregled bibliografske jedinice broj: 138959
Differential regulation of type I cytokines/cytokine receptors on naive and memory B cells
Differential regulation of type I cytokines/cytokine receptors on naive and memory B cells // Abstract book (Immunology Letters. 87 (2003), 1-3)
Shannon: Elsevier, 2003. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 138959 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Differential regulation of type I cytokines/cytokine receptors on naive and memory B cells
Autori
Gagro, Alenka ; Servis, Dražen ; Toellner, Kai-Michael ; Grafton, Gillian ; Taylor, Dale ; Branica, Srećko ; Gordon, John
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract book (Immunology Letters. 87 (2003), 1-3)
/ - Shannon : Elsevier, 2003
Skup
15th European Immunology Congress (EFIS 2003)
Mjesto i datum
Rodos, Grčka, 08.06.2003. - 12.06.2003
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
B cells
Sažetak
B cells can be skewed to differentiate along &laquo ; Type 1&raquo ; or &laquo ; Type 2&raquo ; pathways and correspondingly impact upon the direction of an immune response. However, scant information is available on how this might be regulated. Here we showed that naive and memory tonsilar B cells are remarkably similar in their potential for IL-12 responses as revealed by basal and regulated expression of receptors for this initiating Type 1 cytokine. BCR-engagement provided a priming signal for the induction of IL-12Rb1 which can be potentiated by IFN-g and CD40 ; IL-12 itself prompted the down-regulation of its b1 receptor. IL-12Rb2, essentially absent on both naive and memory cells, was induced solely by IFN-g and then only on a minor subset of each. The expression of WSX-1, an orphan receptor for newly described IL-27, was higher on freshly isolated and non-activated cells. Comparing the potential of naive vs memory B cells for Type 1 cytokine production showed that CD40 ligation induced p40 IL-12, especially in memory cells ; neither subset secreted significant amounts of p70 IL-12. Memory B cells also expressed more p19 IL-23 mRNA with the major signal responsible for its production being BCR triggering. Thus, while B cell subpopulations seem to be limited in their capacity for initiating Type I responses, memory B cells exhibit the potential for their maintenance and amplification.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
