Naslov
The influence of lipoprotein lipase gene polymorphisms on coronary artery disease and plasma lipids in Zagreb cohort

Autori
Pašalić, Daria ; Ferenčak, Goran ; Gršković, Branka ; Cheng, Suzanne ; Fijal, Bonnie ; Šesto, Mihajlo ; Skodlar, Jasna ; Stavljenić Rukavina, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EUROMEDLAB Barcelona 2003 : abstracts ; u: Clinical Chemistry and Laboratory Medicine York (41) 2003 (S1-S608) / - , 2003, S330-S330

Skup
EUROMEDLAB Barcelona 2003

Mjesto i datum
Barcelona, Španjolska, 01.06.2003. - 05.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lipoprotein lipase ; genetic polymorphism ; coronary artery disease

Sažetak
We investigated the relationship between lipoprotein lipase (LPL) gene polymorphisms (-93 T/G, D9N, N291S, and S447X), coronary artery disease (CAD) and lipid traits. We examined Croatian patients with (n=497) and without (n=200) angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR: 0.36 ; p: 0.048). HLD2-cholesterol and apolipoprotein A I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p: 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in the both groups studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p: 0.043 and 0.056, respectively). We conclude that modification in lipoprotein lipase gene might influence lipid levels, and confer risk for CAD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA