Naslov
Antioxidative vitamin substitution in traumatic shock

Autori
Granić, Paula ; Lalić, Zdenka ; Lovrić, Mila ; Stavljenić Rukavina, Ana

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 40 (2002);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
vitamin substitution; traumatic shock

Sažetak
Traumatic shock as an acute and general disorder in perfusion of all organ systems is related to oxidant /antioxidant imbalance. Vitamin E is the most effective lipid soluble antioxidant. The aim of this work was to investigate the level in which the use of antioxidative vitamins E and C decreased adverse effects of lipid peroxidation in traumatic shock. For this purpose, two groups of patients with traumatic shock aged 20-45 years were tested: 1) 10 patients administered the substitution of vitamin E (300 mg) and of C (1000 mg ) during the first 7 days after admission ; 2) 10 patients without substitution. The study was performed during four different periods: at admission, on day 3, on day 7, and on day 15 after admission. Vitamin E was determined by HPLC method using fluorescent detector. Vitamin E values were as follows: 1) 5.9, 5.6, 5.8, 8.6 ng/ml in group with substitution, 2) 5.7, 5.2, 4.7, 6.6 ng/ml in group without substitution. Vitamin E concentration was on day 15 increased by 30% in the group administered vitamin E and vitamin C, thus suggesting that vitamin E and vitamin C substitution might be justified in patients with traumatic shock.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA