Naslov
MTHFR polymorphism in patients with head and neck cancer

Autori
Begonja, Antonija ; Topić, Elizabeta ; Štefanović, Mario ; Šimundić, Ana-Maria

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The third European-American school in forensic genetics and Mayo clinic course in advanced molecular and cellular medicine-Final program and abstracts / Primorac, D ; Erceg Ivkošić, I ; Ivkošić, A ; Vuk-Pavlović, S ; Schanfield, M. - Zagreb : Studio Hrg, 2003

Skup
The third European-American school in forensic genetics and Mayo clinic course in advanced molecular and cellular medicine

Mjesto i datum
Zagreb, Hrvatska, 01.09.2003. - 05.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
MTHFR polymorphism; head and neck cancer

Sažetak
Background: MTHFR is an important enzyme in folate metabolism that converts 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. A functional polymorphism C677T in MTHFR gene results in the change of an alanine to a valine and thus reduces the activity of the MTHFR enzyme. Altered enzyme activity influences DNA methylation and DNA synthesis what makes MTHFR a candidate for a cancer predisposing gene. Aim: To investigate MTHFR polymorphism as a possible genetic risk factor for head and neck cancer. Method: We have studied the possible influence of the MTHFR C677T polymoprhism in a case-control study of 120 healthy subjects and 82 patients with head and neck cancer. MTHFR genotypes were determined by PCR-RFLP. Results: A significant decrease of T allele was observed among the cases in male subgroup (27.4% in cases vs. 34.6% in controls, p=0.007) with odds ratio 0.52, 95% confidence interval 0.32-0.80. Men with heterozygous 677CT genotype (59.3% in controls) had decreased risk for head and neck cancer (odds ratio 0.28, 95% confidence interval 0.14-0.54, p<0.001) compared to CC and TT genotypes. Genotype frequencies were in Hardy-Weinberg equilibrium. Conclusion: Further studies are needed on larger number of subjects to confirm the protective role of MTHFR 677T allele.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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