Naslov
MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo

Autori
Krmpotić, Astrid ; Busch, Dirk ; Bubić, Ivan ; Gebhardt, Friedemann ; Hengel, Hartmut ; Hasan, Milena ; Scalzo, Anthony ; Koszinowski, Ulrich ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Annual Meeting of Croatian Immunological Society, Trakošćan, Croatia / Jonjić, Stipan - Rijeka, 2002

Skup
Annual Meeting of Croatian Immunological Society

Mjesto i datum
Trakošćan, Hrvatska, 22.11.2002. - 24.11.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
MCMV; m152; NK cells; NKG2D

Sažetak
The susceptibility of certain inbred mouse strains to MCMV is related to their inability to generate a strong NK cell response. We addressed here whether the MCMV susceptibility of the BALB/c strain is due to viral functions that control NK cell activation in a strains-specific manner. MCMV expresses two proteins, gp48, and gp40, that are encoded by the genes m06 and m152, respectively ; they down-regulate MHC class-I expression at the plasma membrane. Using MCMV deletion mutants and revertants we found that gp40 but nor gp48 controls NK cell activation. Absence of gp40 improved antiviral NK cell control in BALB/c but not C57BL/6 mice. Down-regulation of H60, the high affinity ligand for the NKG2D recepotr, was the mechanism by which gp40 modulates NK cell activation. Thus, a single herpesvirus protein has a dual function in inhibiting both, the adaptive as well as the innate immune response.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA