Naslov
Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression
(Platelet 5-HT concentrations and suicidal behaviour in reccurent major depression)

Autori
Muck-Šeler, Dorotea ; Jakovljević, Miro ; Pivac, Nela

Izvornik
Journal of affective disorders (0165-0327) 39 (1996), 1; 73-80

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Platelet 5-HT ; recurrent major depression ; suicidality ; sex difference ; psychotic and non-psychotic patient
(Platelet 5-HT ; recurrent major depression ; suicidality ; sex difference ; psychotic and nonpsychotic patient)

Sažetak
Platelet 5-HT concentrations were determined in 84 male and 82 female psychotic and non-psychotic depressed inpatients with various degrees of suicidal behaviour, and in 175 healthy controls. Psychotic patients had higher platelet 5-HT concentrations than non-psychotic depressed patients and healthy controls. A sex difference, i.e. lower platelet 5-HT concentrations in females was found in healthy controls, depressed patients, non-psychotic patients and non-suicidal depressed patients. A negative relationship was shown between platelet 5-HT concantrations and suicidal behaviour. The lowest platelet 5-HT concentrations were associated with the most pronounced suicidal behaviour (with suicidal attempts and with the acts of suicide). The results suggest that the differences in platelet 5-HT concentrations found in depressed patients might be used as a biological marker for suicidal behaviour.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA