Pregled bibliografske jedinice broj: 130150
A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle
A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle // Cell Motility and the Cytoskeleton, 56 (2003), 130-139 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 130150 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle
Autori
Schneider, N. ; Weber, Igor ; Faix, J. ; Prassler, J. ; Müller-Taubenberger, A. ; Köhler, J. ; Burghardt, E. ; Gerisch, G. ; Marriott, G.
Izvornik
Cell Motility and the Cytoskeleton (0886-1544) 56
(2003);
130-139
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lim protein; microtubules; cell cortex; mitosis; cytokinesis
Sažetak
DdLimE regulates cell motility and cytokinesis in Dictyostelium. To specify its function, we generated knock-out mutants and analyzed mitosis by marking the mitotic apparatus with GFP--tubulin. Characteristic of DdLimE-null cells is a late reversal of cytokinesis caused by backward movement of the incipient daughter cells. This process of retro-cytokinesis is accompanied by a delay in disassembly of the mitotic spindle. The length of interphase microtubules is increased and their depolymerization at prophase is impaired. These data indicate that DdLimE links the cortical actin network, where it is located, to the microtubule system, whose dynamics it regulates.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts
- Excerpta Medica
- Index Medicus
