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Pregled bibliografske jedinice broj: 129168

Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities

Raić-Malić, Silvana; Tomašković, Linda; Mrvoš-Sermek, Draginja; Prugovečki, Biserka; Cetina, Mario; Grdiša, Mira; Pavelić, Krešimir; Mannschreck, Albrecht; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities // Book of abstract
Cambridge, 2003. str. 42-42 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 129168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities

Autori
Raić-Malić, Silvana ; Tomašković, Linda ; Mrvoš-Sermek, Draginja ; Prugovečki, Biserka ; Cetina, Mario ; Grdiša, Mira ; Pavelić, Krešimir ; Mannschreck, Albrecht ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract / - Cambridge, 2003, 42-42

Skup
12th SCI-RSC Medicinal Chemistry Symposium

Mjesto i datum
Cambridge, Ujedinjeno Kraljevstvo, 07.09.2003. - 10.09.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
spiropyrans ; 1H and 13C NMR spectra ; single crystal X-ray analysis ; cytostatic activities

Sažetak
The novel racemic indolinospirobenzopyrans (5- 7), indolinospironaphthopyrans (11-14) and indolinospironaphtho-1, 4-oxazine (17) were synthesized by an aldol type of condensation of 1', 3', 3' -trimethyl-2' -methyleneindoline and its 5-substituted derivatives with an appropriately substituted hydroxybenzaldehyde, hydroxynaphthaldehyde or nitrosonaphthol. An unequivocal proof of the stereostructures of 9 and 17 was obtained by their single-crystal X- ray diffraction method. A substituted indoline ring and the benzopyran ring in 9 and the naphtho-1, 4-oxazine moiety in 17 are interconnected via the common chiral atom and disposed almost perpendicularly to each other. The five-membered 2, 3-dihydropyrrolo moiety of the indoline ring adopts an envelope conformation in both structures. Among all compounds in the series, indolinospirobenzopyran (9), containing a methoxy group at the position 6 of the benzopyran ring, exhibited best inhibitory effects on the growth of human CEM (0.68 ug/ml) and Molt4/C8 (0.71 ug/ml) cell lines. Spirobipyridopyran (1) inhibited specifically the growth of human melanoma (HBL) cells but not the growth of normal fibroblasts (WI38).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
0125003
0119632

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Linda Tomašković (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Mirica Grdiša (autor)

Avatar Url Biserka Prugovečki (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Silvana Raić-Malić (autor)

Avatar Url Draginja Mrvoš-Sermek (autor)

Avatar Url Mario Cetina (autor)

Citiraj ovu publikaciju:

Raić-Malić, Silvana; Tomašković, Linda; Mrvoš-Sermek, Draginja; Prugovečki, Biserka; Cetina, Mario; Grdiša, Mira; Pavelić, Krešimir; Mannschreck, Albrecht; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities // Book of abstract
Cambridge, 2003. str. 42-42 (poster, međunarodna recenzija, sažetak, znanstveni)
Raić-Malić, S., Tomašković, L., Mrvoš-Sermek, D., Prugovečki, B., Cetina, M., Grdiša, M., Pavelić, K., Mannschreck, A., Balzarini, J., De Clercq, E. & Mintas, M. (2003) Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities. U: Book of abstract.
@article{article, author = {Rai\'{c}-Mali\'{c}, Silvana and Toma\v{s}kovi\'{c}, Linda and Mrvo\v{s}-Sermek, Draginja and Prugove\v{c}ki, Biserka and Cetina, Mario and Grdi\v{s}a, Mira and Paveli\'{c}, Kre\v{s}imir and Mannschreck, Albrecht and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2003}, pages = {42-42}, keywords = {spiropyrans, 1H and 13C NMR spectra, single crystal X-ray analysis, cytostatic activities}, title = {Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities}, keyword = {spiropyrans, 1H and 13C NMR spectra, single crystal X-ray analysis, cytostatic activities}, publisherplace = {Cambridge, Ujedinjeno Kraljevstvo} }
@article{article, author = {Rai\'{c}-Mali\'{c}, Silvana and Toma\v{s}kovi\'{c}, Linda and Mrvo\v{s}-Sermek, Draginja and Prugove\v{c}ki, Biserka and Cetina, Mario and Grdi\v{s}a, Mira and Paveli\'{c}, Kre\v{s}imir and Mannschreck, Albrecht and Balzarini, Jan and De Clercq, Erik and Mintas, Mladen}, year = {2003}, pages = {42-42}, keywords = {spiropyrans, 1H and 13C NMR spectra, single crystal X-ray analysis, cytostatic activities}, title = {Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities}, keyword = {spiropyrans, 1H and 13C NMR spectra, single crystal X-ray analysis, cytostatic activities}, publisherplace = {Cambridge, Ujedinjeno Kraljevstvo} }

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