Naslov
OPTIMIZATION OF SYNTHESIS OF STOICHIOMETRIC HYDROXYAPATITE FOR BONE TISSUE ENGINEERING APPLICATION

Autori
Marić, Marina Monika ; Bauer, Leonard ; Ivanković, Marica ; Ivanković, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Conference MATRIB 2023- Materials, Tribology & Recycling - BOOK OF ABSTRACTS / Džijan, Ivo ; Šolić, Sanja ; Tropša, Vlado - Zagreb : Hrvatsko društvo za materijale i tribologiju (HDMT), 2023, 41-42

Skup
International Conference MATRIB 2023- Materials, Tribology & Recycling

Mjesto i datum
Vela Luka, Hrvatska, 29.06.2023. - 01.07.2023

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
calcium phosphates, hydroxyapatite, bone tissue engineering

Sažetak
Diseases and fractures of natural bone tissues represent a global issue in medicine. One of the approaches to treat bone defects is bone tissue engineering which aims at development and application of materials for replacing and restoring functions of damaged tissues. An ideal bone graft substitute follows the biomimetic approach for bone regeneration applications. Therefore, calcium phosphates (CaP) were mostly used biomaterials due to their chemical similarity to the mineral part of bone. In this research, wet precipitation method was used to synthesize stoichiometric hydroxyapatite (HAp). The aim was to optimize reaction conditions including precursor type of calcium and phoshorus ions, temperature and reaction time. First, different phosphorous precursors were used, namely ammonium dihydrogen phosphate, urea phosphate and phosphoric acid in the reaction with calcite during 48 h. Then, the effect of calcium precursor (calcite and calcium acetate) on the composition of calcium phosphate was investigated during 48 h. XRD analysis and FTIR spectroscopy indicated the formation of different calcium phosphate phases, especially when different calcium precursor was used. The formation of brushite was detected during the first 6 h of the reaction with calcium acetate, while synthesis with calcite resulted in the formation of octacalcium phosphate pentahydrate during the first 24 h. After 48 h of reaction, hydroxyapatite as the only calcium phosphate phase was detected in all syntheses, indicating the transformation of initially precipitated CaP phases into thermodynamically stable HAp. The morphology of obtained powders was investigated by SEM analysis, while the thermal stability was analyzed by thermogravimetric analysis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Temeljne tehničke znanosti

POVEZANOST RADA